Do you have insights into the clinical aspects of cardiometabolic diseases? And are you motivated by the prospect of leading projects to identify drug targets using genetic data? Then this could be your opportunity to take the next step in your professional journey and join an ambitious Genetics department at Novo Nordisk Research Centre Oxford.
The genetics department are expanding again and looking for a range of talented in silico genetics scientists from recent PhD graduates to innovative individuals who have led many projects across diverse applications within cardiometabolic diseases and traits.
About Novo Nordisk Research Centre Oxford (NNRCO)
NNRCO is our new translational research institute focused on target discovery across the broad spectrum of cardiometabolic disease. We aim to combine the very best of academia, biotech and big pharma, fusing a deep understanding of human genetics, an agile, creative and collaborative culture and drug development. NNRCO will be a world-leading research site focused on asking the big and difficult questions and delivering high impact science.
You can read more about NNRCO at: https://www.novonordisk.com/research-and-development/science-and-innovation/global-r-and-d-centres/novo-nordisk-research-centre-oxford.html
About the department
You will be part of our Department of Genetics led by Sr. Director, Joanna Howson PhD. The department is expanding, and will consist of Principal Scientists, Specialists, Research Scientists, and Postdocs. The focus of this Department is to use data science and human genetics to identify new drug targets, through a range of approaches e.g. high-throughput genetic discovery screens; Mendelian Randomization; pLoF variant screens and precision medicine approaches relevant to type 2 diabetes, obesity, cardiovascular disease, non-alcoholic steatohepatitis (NASH) and other cardiometabolic traits.
We are currently seeking highly motivated, proactive individuals who will benefit from the exceptional research environment for bioinformatics, computational biology, statistical genetics and genetic epidemiology found at NNRCO. We are offering a wide range of job opportunities including Principal scientist, Specialist and Research scientist within the Department of Genetics. The seniority of the role depends on the skill and experience of the candidates, e.g. senior role such as Principal scientist and Specialist will require the experience of leading many projects across a range of in silico genetics projects, and research scientist role are more suitable to candidates who have just finished their PhD and are early in their research career.
As a Principal scientist/Specialist, you would be responsible for conceiving and leading projects to identify drug targets for Cardiometabolic diseases using genetics (e.g. post-GWAS methodologies). To succeed in this, it will be key that you establish collaborations and partnerships with universities and relevant businesses/biotech companies. Collaboration is an established part of our working culture and we believe that we have the biological and technological expertise to be a world class collaboration partner. Within the NNRCO, you will work closely with other statistical geneticists and computational biologists, cell biologists and laboratory scientists. Furthermore, you would be expected to be knowledgeable about cardiometabolic disease genetics (e.g. coronary diseases and renal diseases), and on methodologies and analyses of genetics data (e.g. GWAS, WGS, ’omics integration, interpretation of results from genetic data analyses). Being a Principal Scientist/specialist, you would also be acting as a role model for more junior colleagues, and an important part of your role would be to take responsibility for passing on your knowledge and supporting more junior members of the department in their work.
As a research scientist, you will focus on using human genetics to identify new drug targets for cardiometabolic diseases. In this position you will identify targets using human genetic, genomic and related data from in-house sources, external collaborations and data available publicly to achieve this goal. You will also work alongside other statistical geneticists, computational and laboratory biologists, and with external collaborators to discover and validate new genetic findings and therapeutic targets. We welcome candidates with a good team ethic and the ability to think ‘outside the box? e.g. look beyond the nuclear genome to the mitochondrial genome. You will be encourage to develop your own target discovery projects, This role also suits candidates who enjoy a fast-paced, dynamic environment where creative intellectual independence is actively encouraged.
As a senior bioinformatician, you have the opportunity to identify new drug targets by applying your expertise in genome annotation (i.e. sequence alignment, strand sequencing and in build checking/changing and variant annotation) bioinformatics, data integration (i.e. post GWAS integration methodologies) and analysis , as well as using various methodologies such as big data, and data mining. You will be expected to develop and drive your own projects, while also providing expertise to existing projects within the NNRCO. Our research centre is a collaborative endeavour, and you will work alongside statistical geneticists, computational and laboratory scientists and with external collaborators to discover and validate new genetic findings and therapeutic
Please refer to the further particulars for full details:
At Novo Nordisk, we use our skills, dedication and ambition to help people with diabetes. We offer the chance to be part of a truly global workplace, where passion and engagement are met with opportunities for professional and personal development.
In this position it is required that you have a PhD in a relevant field e.g. statistical genetics, genetic epidemiology, Bioinformatics and computational biology, . As strong statistics background and experience of applying statistical methods for GWAS and post GWAS analyses are essential. Experience of genetics of cardiometabolic diseases would be an advantage e.g. renal, cardiovascular or diabetes.
You will be expected to work well both independently designing and driving the direction of projects, as well as collaboratively as part of a team alongside other inter-disciplinary colleagues in the project team, across NNRCO departments and with external collaborators. You show a positive “can-do” attitude, are flexible, open to new ideas and are results oriented. The positions require proficiency in English and excellent communication and collaboration skills.
About Novo Nordisk Ltd.
Novo Nordisk is a global healthcare company with more than 90 years of innovation and leadership in diabetes care. This heritage has given us experience and capabilities that also enable us to help people defeat other serious chronic conditions: haemophilia, growth disorders and obesity.